Endocrine Abstracts

Providing access to cutting edge technology and expertise in data analysis, the Genomic Services group at the WTCHG are empowering users to drive the pace of research into the underlying mechanisms of disease.The decade since the publication of the first full human genome has seen the development of sequencing technologies, fuelled by competitive pressure and the challenge of the $1000 genome. The latest High Throughput Sequencing platforms from LifeTech...

Pituitary non-functioning adenomas (NFAs), arising mostly from gonadotroph cells, represent the second most common type of pituitary tumour, after prolactinomas. NFAs are monoclonal in origin, but mutations of genes associated with hereditary pituitary syndromes (e.g. MEN1, AIP, CDKN1B, and PRKAR1A), classic oncogenes or tumour suppressor genes are rarely found. We therefore performed whole-exome sequence analysis to determine the tumourigenic events in pituitary NFAs using DN...